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KMID : 0613820070170040575
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Journal of Life Science
2007 Volume.17 No. 4 p.575 ~ p.580
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The Effect of Mulberry Fruits Extracts on Blood Flow Improvement in Ovariectomized Rats
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Choi Kyung-Ha
Shon Jae-Hak
Choi In-Soon
Choi Young-Ju
Bae Song-Ja
Kim Mi-Hyang
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Abstract
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The purpose of this study was to investigate the effect of three different mulberry cultivars extracts on inhibition of platelet aggregation and blood flow improvement. Four groups were surgically ovariectomized (OVX). The fifth group was sham operated. Sprague-Dawley strain female rats were randomly assigned to the following groups : sham-operated rats(Sham), ovariectomized control rats(OVX-Control), ovariectomized rats supplemented with 80% ethanol extracts from fruits of Tajikistan mulberry (OVX-TM), Korea mulberry (OVX-KM) and China mulbery (OVX-CM) at 200 ㎎/㎏ bw/d. The mulberry extracts were orally administrated at 1 ml per day. The body weights of OVX rats were significantly heavier than the sham-operated rats at all values (p＜0.05). The serum triglyceride level was significantly decreased after supplemented with the CM and KM extracts. The serum HDL-cholesterol level in the OVX-KM group was significantly higher than that in the OVX-control group. The passage time of whole blood showed significant correlation with triglyceride but reverse correlation with HDL cholesterol. The ability of platelet aggregation of groups treated with mulberry extracts was less than OVX-control group. Taken these together, mulberry extracts may be used to possibly improve the quality of life in menopausal women.
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KEYWORD
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mulberry, blood passage time, platelet aggregation, ovariectomized rats
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